产品详情
简单介绍：
Anti-DPYD抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-DPYD抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-DPYD
Cat. Number:
Anti-DPYD抗体KL-8288R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to Anti-DPYD抗体an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU. Involvement in disease:
Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing Anti-DPYD抗体to semicoma.
Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing Anti-DPYD抗体to semicoma.
Also known as:
DHP; DHPDHase; Dihydropyrimidine dehydrogenase [NADP+]; Dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; DPYD; DPYD_HUMAN; MGC132008; MGC70799; OTTHUMP00000058954.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, .
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Immunogen: KLH conjugated synthetic peptide derived from human DPYD.
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Predicted Molecular Weight:Anti-DPYD抗体 111kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be Anti-DPYD抗体determined by the end user.
Not yet tested in other applications.
Optimal working dilutions must be Anti-DPYD抗体determined by the end user.
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kl093Hu01 巨噬细胞炎性蛋白1β(MIP1β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 1 Beta (MIP1b)
kl093Mu01 巨噬细胞炎性蛋白1β(MIP1β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 1 Beta (MIP1b)
kl093Po01 巨噬细胞炎性蛋白1β(MIP1β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 1 Beta (MIP1b)
kl093Ra01 巨噬细胞炎性蛋白1β(MIP1β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 1 Beta (MIP1b)
kl093Rb51 巨噬细胞炎性蛋白1β(MIP1β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 1 Beta (MIP1b)
kl093Si01 巨噬细胞炎性蛋白1β(MIP1β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 1 Beta (MIP1b)
kl095Bo01 巨噬细胞炎性蛋白3α(MIP3α)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a)
kl095Ca01 巨噬细胞炎性蛋白3α(MIP3α)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a)
kl095Hu01 巨噬细胞炎性蛋白3α(MIP3α)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a)
kl095Mu01 巨噬细胞炎性蛋白3α(MIP3α)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a)
kl095Po01 巨噬细胞炎性蛋白3α(MIP3α)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a)
kl095Ra01 巨噬细胞炎性蛋白3α(MIP3α)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a)
kl096Bo01 巨噬细胞炎性蛋白3β(MIP3β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Beta (MIP3b)
kl096Ca01 巨噬细胞炎性蛋白3β(MIP3β)多克隆抗体 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Beta (MIP3b)
