产品详情
简单介绍：
Anti-GCLC抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-GCLC抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-GCLC
Cat. Number:
Anti-GCLC抗体KL-8402R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The GCLC gene consists of 16 exons and encodes the 636 amino acid protein g-GCSc (g-glutamylcysteine synthetase heavy subunit), also designated g-L-glutamate-L-cysteine ligase catalytic subunit (GLCLC). g-GCSc is expressed in Anti-GCLC抗体hemocytes, brain, liver and kidney. g-GCSc associates with a regulatory or modifier subunit, g-GCSm (g-glutamylcysteine synthetase light subunit), to form a heterodimer, g-GCS. g-GCS is the first enzyme involved and the rate determining step in glutathione biosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of g-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of g-GCS. Chemopreventive compounds cause increased levels of g-GCSc in kidney tissues, which may protect against chemically induced carcinogenesis. A His370Leu amino acid change in g-GCSc causes deficiencies in activity which are responsible for hemolytic anemia and low red blood cell glutathione levels. Defects in GCLC are the cause of hemolytic anemia.
Also known as:
Gamma ECS; Gamma GCS; Gamma Anti-GCLC抗体glutamylcysteine synthetase; Gamma-ECS; Gamma-glutamylcysteine synthetase; GCL; GCLC; GCLM; GCS; GCS Heavy Chain antibody GLCL; GLCLC; GLCLR; Glutamate cysteine ligase catalytic subunit; Glutamate cysteine ligase (gamma glutamylcysteine synthetase) regulatory (30.8kD); Glutamate cysteine ligase catalytic subunit; Glutamate cysteine ligase modifier subunit; Glutamate cysteine ligase regulatory protein; Glutamate cysteine ligase regulatory subunit; Glutamate--cysteine ligase catalytic subunit; GSH1_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic Anti-GCLC抗体peptide derived from human GCLC.
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Predicted Molecular Weight: 73kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
Not yet tested in other applications. Anti-GCLC抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-GCLC抗体
Optimal working dilutions must be determined by the end user.
kl284Ga01 肝素辅因子Ⅱ(HCⅡ)多克隆抗体 Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Hu01 肝素辅因子Ⅱ(HCⅡ)多克隆抗体 Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Mu01 肝素辅因子Ⅱ(HCⅡ)多克隆抗体 Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Ra01 肝素辅因子Ⅱ(HCⅡ)多克隆抗体 Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Rb51 肝素辅因子Ⅱ(HCⅡ)多克隆抗体 Polyclonal Antibody to Heklin Cofactor II (HCII)
kl292Ga01 α-胞衬蛋白(SPTAN1)多克隆抗体 Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl292Hu01 α-胞衬蛋白(SPTAN1)多克隆抗体 Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl292Mu01 α-胞衬蛋白(SPTAN1)多克隆抗体 Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl292Ra01 α-胞衬蛋白(SPTAN1)多克隆抗体 Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl293Bo01 谷氨酸脱氢酶(GDH)多克隆抗体 Polyclonal Antibody to Glutamate Dehydrogenase 1 (GDH)
kl293Hu01 谷氨酸脱氢酶(GDH)多克隆抗体 Polyclonal Antibody to Glutamate Dehydrogenase 1 (GDH)
kl293Mu01 谷氨酸脱氢酶(GDH)多克隆抗体 Polyclonal Antibody to Glutamate Dehydrogenase 1 (GDH)
kl293Ra01 谷氨酸脱氢酶(GDH)多克隆抗体 Polyclonal Antibody to Glutamate Dehydrogenase 1 (GDH)
kl295Bo01 谷胱甘肽过氧化酶1(GPX1)多克隆抗体 Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1)
kl295Hu01 谷胱甘肽过氧化酶1(GPX1)多克隆抗体 Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1)
kl295Mu01 谷胱甘肽过氧化酶1(GPX1)多克隆抗体 Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1)
kl295Po01 谷胱甘肽过氧化酶1(GPX1)多克隆抗体 Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1)
kl295Ra01 谷胱甘肽过氧化酶1(GPX1)多克隆抗体 Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1)
