产品详情
简单介绍：
Anti-Geminin抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-Geminin抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-Geminin
Cat. Number:
Anti-Geminin抗体KL-9536R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during Anti-Geminin抗体the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of geminin fluctuates throughout the cell cycle with geminin levels lowest at G1. Throughout S, G2 and M phases, geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the the degradation of geminin during mitosis and the absence of geminin throughout G1 phase. Geminin degradation is mediated by the anaphase-promoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitin-mediated proteolysis.
Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of geminin fluctuates throughout the cell cycle with geminin levels lowest at G1. Throughout S, G2 and M phases, geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the the degradation of geminin during mitosis and the absence of geminin throughout G1 phase. Geminin degradation is mediated by the anaphase-promoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitin-mediated proteolysis.
Also known as:
DNA replication inhibitor; Gem; Anti-Geminin抗体GEMI_HUMAN; Geminin; Geminin DNA replication inhibitor; GMNN; OTTHUMP00000039393.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .
●
Immunogen: KLH conjugated synthetic peptide derived from human Geminin.
●
Predicted Molecular Weight: 23kDa.Anti-Geminin抗体
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:50-200
Not yet tested in other applications. Anti-Geminin抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-Geminin抗体
Optimal working dilutions must be determined by the end user.
kl698Mu01 巨噬细胞移动抑制因子(MIF)多克隆抗体 Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)
kl698Ra01 巨噬细胞移动抑制因子(MIF)多克隆抗体 Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)
kl699Hu01 环加氧酶2(PTGS2)多克隆抗体 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 2 (PTGS2)
kl699Mu01 环加氧酶2(PTGS2)多克隆抗体 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 2 (PTGS2)
kl699Ra01 环加氧酶2(PTGS2)多克隆抗体 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 2 (PTGS2)
kl700Hu01 棕榈酰化膜蛋白6(MPP6)多克隆抗体 Polyclonal Antibody to Membrane Protein, klmitoylated 6 (MPP6)
kl702Pl01 硫氧化还原蛋白(Trx)多克隆抗体 Polyclonal Antibody to Thioredoxin (Trx)
kl703Hu01 硫氧还蛋白还原酶1(TrxR1)多克隆抗体 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1)
kl703Mu01 硫氧还蛋白还原酶1(TrxR1)多克隆抗体 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1)
kl704Po01 载脂蛋白E(APOE)多克隆抗体 Polyclonal Antibody to Apolipoprotein E (APOE)
kl704Rb51 载脂蛋白E(APOE)多克隆抗体 Polyclonal Antibody to Apolipoprotein E (APOE)
kl706Hu01 内脏脂肪特异性丝氨酸蛋白酶抑制因子(Vaspin)多克隆抗体 Polyclonal Antibody to Visceral Adipose Tissue Derived Serine Protease Inhibitor (Vaspin)
kl706Mu01 内脏脂肪特异性丝氨酸蛋白酶抑制因子(Vaspin)多克隆抗体 Polyclonal Antibody to Visceral Adipose Tissue Derived Serine Protease Inhibitor (Vaspin)
kl706Ra01 内脏脂肪特异性丝氨酸蛋白酶抑制因子(Vaspin)多克隆抗体 Polyclonal Antibody to Visceral Adipose Tissue Derived Serine Protease Inhibitor (Vaspin)
kl708Hu01 δ-促睡眠肽(δSIP)多克隆抗体 Polyclonal Antibody to Delta-Sleep Inducing Peptide (dSIP)
kl709Hu01 Toll样受体9(TLR9)多克隆抗体 Polyclonal Antibody to Toll Like Receptor 9 (TLR9)
kl711Hu01 肝素酶(HPA)多克隆抗体 Polyclonal Antibody to Heklanase (HPA)
kl711Mu01 肝素酶(HPA)多克隆抗体 Polyclonal Antibody to Heklanase (HPA)
kl712Mu01 钠/钾离子转运ATP酶β3肽(ATP1β3)多克隆抗体 Polyclonal Antibody to ATkle, Na+/K+ Transporting Beta 3 Polypeptide (ATP1b3)
kl713Hu01 CCAAT增强子结合蛋白β(CEBPβ)多克隆抗体 Polyclonal Antibody to CCAAT/Enhancer Binding Protein Beta (CEBPb)
