产品名称：Anti-phospho-IRE1 (Ser724)抗体

Cat. Number:

Anti-phospho-IRE1 (Ser724)抗体KL-16698R

Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes Anti-phospho-IRE1 (Ser724)抗体involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes. In response to stress, sensors for the ER mammalian cells activate IRE1α and IRE1β, which then results in the phosphorylation of JNK (Jun N-Terminal Kinase) and the activation of the cellular MAP kinase pathway.

Also known as:

IRE1 (phospho S724); p-IRE1 (phospho S724);Anti-phospho-IRE1 (Ser724)抗体 Endoplasmic reticulum (ER) to nucleus signalling 1; Endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signaling 1; ER to nucleus signalling 1; ERN 1; ERN1; ERN1_HUMAN; hIRE 1p; hIRE1p; Inositol requiring 1; Inositol requiring 1, S. cerevisiae, homolog of; Inositol requiring enzyme 1, S. cerevisiae, homolog of; Inositol requiring protein 1; inositol-requiring enzyme 1; Inositol-requiring protein 1; IRE 1; IRE 1a; IRE 1P; Ire1 alpha; Ire1-alpha; IRE1a; Ire1alpha; IRE1P; MGC163277

Specificity:

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. Anti-phospho-IRE1 (Ser724)抗体
Optimal working dilutions must be determined by the end user.kl947Ra01 顶体蛋白(ACR)多克隆抗体 Polyclonal Antibody to Acrosin (ACR)
kl210Ra01 血小板反应蛋白解整合素金属肽酶10(ADAMTS10)多克隆抗体 Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10)
kl599Ra01 肌动蛋白相关蛋白2/3复合体亚基4(ARPC4)多克隆抗体 Polyclonal Antibody to Actin Related Protein 2/3 Complex Subunit 4 (ARPC4)
kl231Ra01 锌结合α2-糖蛋白1(αZGP1)多克隆抗体 Polyclonal Antibody to Alpha-2-Glycoprotein 1, Zinc Binding (aZGP1)
kl833Ra01 补体因子D(CFD)多克隆抗体 Polyclonal Antibody to Complement Factor D (CFD)
kl002Ra01 CREB结合蛋白(CREBBP)多克隆抗体 Polyclonal Antibody to CREB Binding Protein (CREBBP)
kl964Ra01 组织蛋白酶B(CTSB)多克隆抗体 Polyclonal Antibody to Cathepsin B (CTSB)
kl468Ra01 衰变加速因子(DAF)多克隆抗体 Polyclonal Antibody to Decay Accelerating Factor (DAF)
kl422Ra01 衰老关键蛋白3(FBLN3)多克隆抗体 Polyclonal Antibody to Fibulin 3 (FBLN3)
kl708Ra01 法尼基二磷酸法尼基转移酶1(FDFT1)多克隆抗体 Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1)
kl915Ra01 成纤维细胞生长因子13(FGF13)多克隆抗体 Polyclonal Antibody to Fibroblast Growth Factor 13 (FGF13)
kl994Ra01 谷胱甘肽过氧化酶5(GPX5)多克隆抗体 Polyclonal Antibody to Glutathione Peroxidase 5 (GPX5)
kl515Ra01 白介素1受体关联激酶2(IRAK2)多克隆抗体 Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 2 (IRAK2)
kl622Ra01 多聚蛋白1(MMRN1)多克隆抗体 Polyclonal Antibody to Multimerin 1 (MMRN1)
kl433Ra01 肌球蛋白ⅠD(MYO1D)多克隆抗体 Polyclonal Antibody to Myosin ID (MYO1D)
kl268Ra01 苯酚磺基转移酶(PST)多克隆抗体 Polyclonal Antibody to Phenol Sulfotransferase (PST)
kl722Ra01 基质细胞衍生因子4(SDF4)多克隆抗体 Polyclonal Antibody to Stromal Cell Derived Factor 4 (SDF4)
kl623Mu01 表面活性物质关联蛋白C(SPC)多克隆抗体 Polyclonal Antibody to Surfactant Associated Protein C (SPC)
kl951Mu01 43kDa Tar DNA结合蛋白(TDP43)多克隆抗体 Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)
kl551Rb51 碱性成纤维细胞生长因子(FGF2)多克隆抗体 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2)