产品详情
简单介绍：
Anti-JDP2抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-JDP2抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-JDP2
Cat. Number:
Anti-JDP2抗体KL-17200R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
c-Jun dimerization protein (JDP) 2 binds cAMP-response element (CRE) as a homodimer or as a heterodimer with ATF-2 and c-Jun. This dimerization allows JDP2 to repress CRE-dependent transcription. JDP2 is phosphorylated by c-Jun N-terminal kinase at Thr 138. JDP2 contains a basic leucine zipper (bZIP) region for DNA-binding. The bZIP region of JDP2 interacts with the DNA binding domain (DBD) of progesterone receptor (PR) in mammalian cells. Two other coactivators, creb binding protein (CBP)Anti-JDP2抗体 and p300 CBP-associated factor (PCAF), also associate with JDP2. Thus, JDP2 appears to stimulate the N-terminal activation function domain of PR by docking to the DBD and facilitation PR interaction with other coactivators. The expression of JDP2 in PR-targeted tissues and cells supports the role for JDP2 in PR function. In addition, JDP2 may play an important role in controlling the commitment of F9 embryonal carcinoma cells to differentiation. In undifferentiated F9 cells, JDP2 recruits HDAC3 and binds the differentiation response element within the c-jun promoter. Retinoic acid-induction replaces the JDP2/HDAC3 complex with PCAF and subsequently allows the transcription of c-Jun for F9 differentiation. The gene encoding human JDP2 maps to chromosome 14q24.2.
Also known as:
Jdp2; JDP2_HUMAN;Anti-JDP2抗体 Jun dimerization protein 2; JUNDM2; Progesterone receptor co-activator.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human JDP2.
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Predicted Molecular Weight: 19kDa.
Storage:
Shipped at 4℃, Store at -20℃ Anti-JDP2抗体(Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-JDP2抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-JDP2抗体
Optimal working dilutions must be determined by the end user.
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