产品详情
简单介绍：
Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。 Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)
Cat. Number:
Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体KL-3316R
Quantity size:
0.1ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体as cell death. P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
Also known as:
PAK1 + PAK2 + PAK3 (phospho T423 + T402 + T421); Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体PAK1 + PAK2 + PAK3 (phospho Thr423 + Thr402 + Thr421); Pak2(phospho T402); Pak1(phospho T423); PAK1(phospho T402); PAK2(phospho T423); PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka; PAKalpha; Protein kinase MUK2; STE20 homolog (yeast); Alpha PAK; p21/Cdc42/Rac1 activated kinase 1; CB422; EC 2.7.11.1; Gamma PAK; hPAK65; Kinase; p21 (CDKN1A)-activated kinase 2a; p21 activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein Cdc42 Rac activated kinase 2; p21-activated kinase, 65-KD; p21-activated protein kinase I; p21CDKN1A activated kinase 2; p58; p65PAK; PAK 2; PAK65; PAKgamma; S6 H4 kinase; Serine threonine protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; p21-activated kinase 3; PAK-3; Beta-PAK; PAK1_HUMAN; PAK2_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体Dog, Pig, Cow, Rabbit, .
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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PAK1 around the phosphorylation site of Thr423.
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Predicted Molecular Weight: 60kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)抗体
Optimal working dilutions must be determined by the end user.
