Smartox-Biotech
Smartox Biotechnology
离子通道研究用多肽**的专业化生产商
Smartox Biotechnology是全球唯壹一家专门生产动物毒液多肽**，用于细胞离子通道功能研究的生物医药公司。多肽**在生物制药领域具有重要的使用价值。
Smartox Biotechnology于2009年由来自Grenoble神经科学研究所(Grenoble Institute of Neuroscience)的Michel de waard博士创立,Smartox Biotechnology专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为**）。De Waard博士研究离子通道与**多肽的关系，尤其是鉴定、开发**多肽作为**性分子或细胞穿透肽(cell penetrating peptides, CPP)。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。2010年，Smartox Biotechnolgy被法国研究部(Ministry of Research)授予“新兴企业OSEO奖(OSEO prize for emerging businesses)”。
总之，Smartox Biotechnology提供一系列高质量、具开创价值的多肽**。这些化合物在离子通道 研究中具有高的亲和性和选择性，是相应领域科学研究理想的生物**提供商和贴心的合作伙伴。
Smartox Biotechnology的**产品包括：
钠离子通道(Sodium channel)
|
Toxin name |
Catalog # |
Target |
|
Phrixotoxin-3 |
13PHX003 |
Selective blocker of Nav1.2 |
|
µ-conotoxin GIIIB |
CON020 |
Selective blocker of Nav1.4 |
|
µ-conotoxin CnIIIC |
CON021 |
Selective blocker of Nav1.4 |
|
μ-conotoxin PIIIA |
08CON006 |
Selective blocker of Nav1.4 |
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Jingzhaotoxin-III |
12JZH003 |
Selective blocker of Nav1.5 |
|
ProTx-II |
07PTX002 |
Selective blocker of Nav1.7 |
|
ProTx-II Biotin |
12PTB002 |
Selective blocker of Nav1.7 |
|
ProTx-I |
12PTX001 |
Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7 |
|
Huwentoxin-I |
07HWT001 |
Blocker of TTX-S |
|
Huwentoxin-IV |
08HWT002 |
Blocker of TTX-S |
|
Hainantoxin-III |
13HTX003 |
Blocker of TTX-S |
|
Hainantoxin-IV |
12HTX001 |
Blocker of TTX-S |
|
GsAF-I |
12GSF001 |
Blocker of TTX-S |
|
GsAF-II |
12GSF002 |
Blocker of TTX-S |
钾离子通道(Potassium channel)
|
KCa channels |
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|
Toxin name |
Catalog # |
Target |
Description |
|
Apamin |
08APA001 |
SK1, SK2, SK3 |
|
|
Charybdotoxin |
11CHA001 |
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6 |
|
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Iberiotoxin |
12IBX001 |
KCa1.1 |
|
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Leiurotoxin 1 (Scyllatoxin) |
10LEI001 |
SK1, SK2, SK3 |
|
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Tamapin |
10TAM001 |
SK1, SK2, SK3 |
|
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Kaliotoxin-1 |
08KTX002 |
BK, Kv1.1, Kv1.2, Kv1.3 |
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Kv channels |
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ShK |
08SHK001 |
Kv1.3, Kv1.1, Kv1.4, Kv1.6 |
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TMR-ShK |
SAT001 |
Kv1.3, Kv1.1 |
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Margatoxin |
08MAG001 |
Kv1.3 |
|
|
(Dap22)-ShK |
13SHD001 |
Kv1.3 |
|
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ADWX-1 |
13ADW001 |
Kv1.3 |
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HsTx1 |
08NEU001 |
Kv1.3, Kv1.2 |
|
|
Agitoxin-2 |
13AGI002 |
Kv1.3, Kv1.1 |
|
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Maurotoxin |
08MAR001 |
Kv1.2, KCa3.1 |
|
|
Guangxitoxin 1E |
11GUA002 |
Kv2.1, Kv2.2 |
|
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Stromatoxin 1 NEW |
SCT01 |
Kv2.1, Kv2.2 |
|
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Kaliotoxin-1 |
08KTX002 |
BK, Kv1.1, Kv1.2, Kv1.3 |
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Charybdotoxin |
11CHA001 |
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6 |
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Phrixotoxin-2 |
PHX002 |
Kv4.2, Kv4.3 |
|
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AmmTx3 NEW |
AMX001 |
A-type potassium channels |
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Inwardly rectifying potassium channels |
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TertiapinQ |
08TER001 |
Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1 |
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hERG/Kv11.1 |
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|
BeKm-1 |
13BEK001 |
ERG1 |
|
钙离子通道(Calcium channel)
|
High voltage-gated Ca2+ channels |
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|
Toxin name |
Catalog# |
Target |
Description |
|
ω-agatoxin IVA |
11AGA001 |
P/Qtype |
|
|
ω-Conotoxin MVIIC |
08CON002 |
P/Qtype, N-type |
|
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ω-Conotoxin MVIIA |
08CON001 |
N-type |
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ω-Conotoxin GVIA |
08CON003 |
N-type |
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ω-Conotoxin SO3 |
08CON013 |
N-type |
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Huwentoxin I |
07HWT001 |
N-type |
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ProTx-II |
07PTX002 |
T-type, L-type |
|
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Intermediate voltage-gated Ca2+ channels |
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SNX482 |
08SNX002 |
R-type |
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Low voltage-gated Ca2+ channels |
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ProTx-I |
12PTX001 |
T-type |
|
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ProTx-II |
07PTX002 |
T-type, L-type |
|
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Maurocalcine |
07PAU001 |
Ryr1 |
|
氯离子通道(Chloride channel)
|
Toxin name |
Catalog # |
Target |
Description |
|
Chlorotoxin |
08CHL001 |
Blocker of small conductance Cl- channels |
|
|
GaTx1 |
13GTX001 |
Selective blocker of CFTR channel |
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|
GaTx2 |
10GTX002 |
Selective blocker of ClC-2 channel |
乙酰胆碱受体(Acetylcholine receptor)
|
Toxin name |
Catalog # |
Target |
Description |
|
α-conotoxin PeIA |
13CON017 |
α9α10, α3β2 subunits |
|
|
αC-Conotoxin PrXA |
13CON016 |
α1/β1/ε/δ, α1/β1/γ/δ subunits |
|
|
Waglerin-1 |
12WAG001 |
MusclenAChR |
|
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α-conotoxin MI |
08CON012 |
α1/δsubunits |
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α-conotoxin GI |
08CON005 |
α/δsite |
|
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α-conotoxin IMI |
08CON011 |
α7 homomeric nAChR |
|
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α-conotoxin GID |
CON019 |
含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)
Conantokin-G选择性、特异性抑制含NR2B的NMDAR。Conantokin-G能剂量依赖性抑制Ca2+内流，抑制NMDA诱导的兴奋性中毒效应。研究表明，在小鼠皮层神经元，Conantokin-G阻滞NMDA引发的电流信号的IC50值为480 nM。
酸敏感离子通道(ASIC channel, Acid-Sensing Ion Channel)
|
Toxin name |
Catalog # |
Target |
Description |
|
APETx2 |
07APE002 |
Selective blocker of ASIC3 |
|
|
Psalmotoxin1/PcTx1 |
13PCT001 |
Selective blocker of ASIC1a |
|
|
Ugr9-1 |
13UGR001 |
Blocker of ASIC3 |
瞬时受体电位(TRP channel, transient receptor potential)
|
Toxin name |
Catalog # |
Target |
Description |
|
GsMTx4 |
08GSM001 |
TRPC, TRPA |
|
|
Vanillotoxin3 |
10VAN003 |
Activator of TRPV1 |
|
|
ProTx-I |
12PTX001 |
Antagonist of TRPA1 |
嘌呤能通道(Purinergic channel)
Purotoxin-1
选择性抑制P2X3受体。100 nM Purotoxin-1 (PT-1)选择性抑制P2X3受体通道，在大鼠DRG神经元上，使用膜片钳实验表明：PT-1对电压门控通道和TRPV1均无抑制效应。10 µM ATP和100 µM α,β Methylene-ATP浓度下Purotoxin-1对P2X3受体有选择性作用，在该ATP浓度下Purotoxin-1对P2X2和杂化二聚体P2X2/3并无激动作用。
Purotoxin-1对疼痛的潜在**作用。
其它膜受体通道(Others)
Smartox Biotechnology还提供其他类型的膜受体抑制剂：
|
Toxin name |
Catalog# |
Target |
|
Morphiceptin |
011CAS001 |
Agonist of µ-opoid receptors |
|
Lys-conopressin G |
11CON14 |
Vasopressin-like peptide |
|
GsMTx4 |
08GSM001 |
Mechano sensitive ion channels |
|
Obtustatin |
10OBT001 |
Blocks the binding of α1β1 integrin to collagen IV |
|
Rho-Conotoxin TIA |
CON022 |
Blocks α1-adrenergic receptor |
