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Trilink

Trilink

Trilink

  

国别:美国Trilink

成立于1999年的TriLink BioTechnologies是一家私有公司,总部位于美国加州圣地亚哥,生意遍布全球70余个国家和地区


TriLink BioTechnologies  Nucleotides


It is likely that among TriLink’s wide selection of modified nucleoside triphosphates (NTPs) you will find a compound to suit your application. We stock over 150 modified compounds, including Aminoallyl, Biotin and 2' Fluoro nucleotides. In addition, we offer specialty modified nucleotides such as bisphosphates, a series of monophosphates and CAP and mCAP. Whether your studies involve indirect DNA labeling, cDNA synthesis, nuclease resistance or a new application, we have the right modified NTP. Additionally, our nucleic acid chemists are experts in the synthesis of unique NTPs. Please inquire for larger quantities or specific concentrations.


TriLink BioTechnologies  Custom Chemistry


Our custom chemistry and contract research services include synthesis of unique phosphoramidites and polyphosphates, including mono-, di- and triphosphates, and other small molecules. If the small molecule your research requires is not commercially available, contact us. Collectively, our R&D team has decades of experience developing and optimizing nucleic acid synthesis schemes.



TriLink BioTechnologies是世界上*专业核酸修饰和标记专家,其砖利的热启动DNTP和热启动引物是广大诊断试剂开发商的启明星,是高难度PCR(如高GC含量,长片段PCR,基因克隆)的又一把利器


A New Approach to Early Phase Therapeutic GMP Manufacturing

For over 20 years, we’ve been industry leaders synthesizing high quality research and diagnostic grade material, especially difficult and unusual constructs. Now we’re combining our expertise with a new state-of-the art GMP manufacturing facility to expand our services into mRNA and oligonucleotide therapeutics. 

We offer single-batch or multiple-batch synthesis for IND-enabling tox studies and early phase clinical studies. With a wide variety of synthesis scales so that you can get just the amount of material you need for your particular study. Because we don’t require large scale synthesis, we can deliver your material quickly and at an affordable price. We provide drug substances plus supporting documentation to streamline the IND submission process and carry you through to clinical trials—saving you time and money.

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State-of-the-Art Facility 
Our new, 2,000 square foot GMP facility is dedicated to manufacturing therapeutic products and is ISO certified by Lloyd’s Register. The controlled labs feature:
  • Validated ISO Class 7 and Class 8 clean rooms 
  • Compliance with ICH Q7, CFR 210 and other phase-appropriate GMPs
  • Single pass, HEPA filtered air system 
  • Routine monitoring for temperature, pressure, humidity and particle count 
  • Fully gowned staff
  • Facilities, processes, equipment and computerized systems are validated (IQ/OQ) and maintained in a validated state
Available Products 
Manufacturing of therapeutic grade material is available for: 
  • mRNA 
  • Long RNA 
  • Oligonucleotides 
  • Nucleotides & nucleosides 
  • Aptamers
Getting Started with Therapeutic GMP Manufacturing
To begin discussions and obtain a quote for your project, please send us a request. We’ll start with an intake meeting, where we’ll discuss your project, expectations and timelines. From there, we’ll work with you to determine the most effective and efficient process for your particular project. Although we may customize each project to meet your specific needs, the basic steps are outlined below. 

  • Information transfer
  • Technology transfer
  • Trial synthesis
  • Scale Up
  • Finalize process and documentation


Gram Scale  

Affordable Custom Synthesis
Up to gram scales of mRNA and long RNA (multiple kilobases)

 

Editing   Genome Editing & Manipulation Tools
Zinc-finger nucleasesTALENSCRISPR and recombinases

 

Gene Replacement  

Gene Replacement, Immunotherapy & Delivery Optimization
Featuring reporter gene mRNA, secreted factors like Factor IX and hAAT

 

GMP  

GMP Manufacturing
Fully traceable from research to clinical grade

 

Stem Cell   Reprogramming Factors
mRNA for non-integrating generation of iPSCs

 

Please contact us to discuss your path to pharmaceutical GMP manufacturing.



CleanAmp™ Hot Start PCR

CleanAmp™ Hot Start PCR is a patented technology developed under SBIR grants from the NIH. CleanAmp™ Hot Start PCR products provide a specific, sensitive and flexible alternative to Hot Start DNA polymerases. TriLink has applied their expertise in modified nucleic acid chemistry to develop chemically modified dNTPs and primers that enable Hot Start PCR using standard Taq DNA polymerase. Simply swap out the standard dNTPs or primers in your PCR assay for the corresponding CleanAmp™ product to create a Hot Start PCR reaction. CleanAmp™ products are ideal for applications such as RT-PCR, multiplex PCR, digital PCR, fast PCR, end-point PCR and real-time PCR (including real-time RT-PCR and fast real-time PCR). CleanAmp™ Hot Start PCR products offer: 

• Compatibility with all DNA polymerases and PCR applications 
• Unparalleled specificity and sensitivity due to significantly reduced non-specific amplification 
• Easy assay development with minimal optimization 
• Increased product yield 
• High amplification efficiency with short and long amplicons (up to 23kb) 
• Significant cost savings over other Hot Start technologies, including affordable licensing opportunities
CleanAmp dNTP Specificity

CleanAmp™ dNTP Mix eliminates primer dimer formation.


CleanAmp Primer Specificity

CleanAmp™ Primers improve PCR performance in systems prone to (A) primer dimer formation and (B) mis-priming.

Activation of CleanAmp™ Products occurs during the initial heat cycle of Hot Start PCR and each subsequent denaturation step, releasing just enough reagent to allow efficient amplification. By limiting the amount of active reagent during the early cycles when the target is in low concentration, CleanAmp™ significantly reduces background amplification to achieve a reduction or even an elimination of primer dimer and mis-priming.

CleanAmp dNTPs


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